Environmental control of Th17 differentiation

Cytokine regulation of Th17 differentiation

Introduction The random rearrangement of adaptive antigen receptors allows for incredible diversity of antigen receptor specificity but comes at the cost of creating potentially autoreactive T and B lymphocytes. Although many potentially autoreactive clones are deleted during development or are prevented from causing disease by the various mechanisms of peripheral tolerance, others go on to ind...

Estradiol Inhibits Th17 Cell Differentiation

Sox5 and Th17 cell differentiation

Sox (SRY-related high-mobility-group (HMG)-box) transcription factors, which are comprised of 20 genes containing a conserved HMG DNA-binding domain, are divided into 8 groups (from A to H) according to structural homologies [reviewed in 1-2]. SoxC group, which is composed of Sox4, Sox11, and Sox12, has a HMG box domain and a transactivation domain and plays important roles in the development o...

The Role Of Notch In Th17 Differentiation

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ICER is requisite for Th17 differentiation

Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM). Here we report that ICER is predominantly expressed in Th17 cells through the IL-6-STAT3 pathway and binds to the Il17a promoter, where it facilitates the accumulation of the canonical enhancer RORγt. In vitro differentiation from naive ICER/CREM-deficie...